بررسی اثر اسید آسکوربیک در پیشگیری از نفروپاتی ناشی از ماده حاجب در بیماران دیابتیک

Introduction: Contrast induced nephropathy (CIN) is one the complications resulting from coronary catheterization and is regarded as one of the reasons of acute kidney failure. Therefore, this study aimed to investigate the effect of ascorbic acid in the prevention of CIN in Yazd in 2012. Methods: This study involves a double blind clinical trial in which 90 Diabetic patients with coronary catheterization have attended. The patients were divided randomly into two groups: control group and treatment group. Demographic and clinical data were collected by a questionnaire. Treatment group received vitamin C (2 grams) 2 hours before the intervention and the control groups were given 2 grams of the Placebo. The GFR (Glomerular filtration rate), BUN (Blood Urea Nitrogen), and Cr (Creatinin) were measured and compared after 2-3 days. Results: The CIN in treatment group was about 3 patients (7.7%) and was 7 (16.7%) in the control group. Thus, no significant difference was observed though, there was a significant difference between Cr and GFR before and after the treatment in vitamin C group (PV= 0.006, PV=0.001), but these differences were not significant in the placebo group.(PV=0.661, PV=0.747). Moreover, considering the participants’ age, sex and their primary function of kidney, a significant difference had not appeared due to the incidence of CIN between the two groups. Conclusion: Our study did not show Ascorbic Acid effects in prevention of CIN in Diabetic patients.